Solvent tolerance in bacteria: Role of efflux pumps and cross-resistance with antibiotics

Pedro Fernandes, Bruno Sommer Ferreira, Joaquim Manuel Sampaio Cabral

Resultado de pesquisarevisão de pares

123 Citações (Scopus)

Resumo

Microorganisms have mechanisms that enable them to tolerate lethal concentrations of toxic compounds. This feature has been exploited in a wide range of bioprocesses that range from bioremediation applications to production of fine chemicals in two-phase reaction media. The ability to modify the physical properties of cellular membranes has long been put forward as a protection mechanism that enables microorganisms to tolerate solvents. More recently, efflux pumps have been shown to extrude deleterious compounds, such as antibiotics, drugs and solvents. An understanding of the mechanism of solvent tolerance and its relationship to cross-resistance of pathogenic organisms to antibiotics has major impact on the type and use of disinfectants and disinfecting procedures. The presence of solvents in the growth environment may lead to the emergence of solvent resistant strains and, therefore, overuse may propagate resistant microbial variants. In this paper, mechanisms that lead to solvent tolerance of microbes and accompanying specific antibiotic resistance are reviewed.

Idioma originalInglês
Páginas (de-até)211-216
Número de páginas6
RevistaInternational Journal of Antimicrobial Agents
Volume22
Número de emissão3
DOIs
Estado da publicaçãoPublicadas - 1 set. 2003

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