TY - JOUR
T1 - Skeletal muscle–adipose tissue–tumor axis
T2 - Molecular mechanisms linking exercise training in prostate cancer
AU - Rocha-Rodrigues, Sílvia
AU - Matos, Andreia
AU - Afonso, José
AU - Mendes-Ferreira, Miguel
AU - Abade, Eduardo
AU - Teixeira, Eduardo
AU - Silva, Bruno
AU - Murawska-Ciałowicz, Eugenia
AU - Oliveira, Maria José
AU - Ribeiro, Ricardo
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Increased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these effects are mediated by ET-induced synthesis and secretion of several proteins, known as myo-and adipokines. Together, myokines and adipokines may act in an endocrine-like manner to favor communication between skeletal muscle and WAT, as they may work together to improve whole-body metabolic health. This crosstalk may constitute a potential mechanism by which ET exerts its beneficial role in the prevention and treatment of PCa-related disorders; however, this has not yet been explored. Therefore, we reviewed the current evidence on the effects of skeletal muscle–WAT–tumor crosstalk in PCa, and the potential mediators of this process to provide a better understanding of underlying ET-related mechanisms in cancer.
AB - Increased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these effects are mediated by ET-induced synthesis and secretion of several proteins, known as myo-and adipokines. Together, myokines and adipokines may act in an endocrine-like manner to favor communication between skeletal muscle and WAT, as they may work together to improve whole-body metabolic health. This crosstalk may constitute a potential mechanism by which ET exerts its beneficial role in the prevention and treatment of PCa-related disorders; however, this has not yet been explored. Therefore, we reviewed the current evidence on the effects of skeletal muscle–WAT–tumor crosstalk in PCa, and the potential mediators of this process to provide a better understanding of underlying ET-related mechanisms in cancer.
KW - Cancer
KW - Periprostatic fat
KW - Physical activity
KW - Skeletal muscle
KW - Tumor microenvironment
KW - Visceral adiposity
UR - http://www.scopus.com/inward/record.url?scp=85104533166&partnerID=8YFLogxK
U2 - 10.3390/ijms22094469
DO - 10.3390/ijms22094469
M3 - Review article
C2 - 33922898
AN - SCOPUS:85104533166
SN - 1661-6596
VL - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 9
M1 - 4469
ER -