Preclinical assessment of an antibiotic-free cationic surfactant-based cellulose hydrogel for sexually and perinatally transmitted infections

Rita D.A. Calado, Bárbara B. Mendes, João Conniot, João M.J.M. Ravasco, Daniel Sobral, Carolina Ferreira, Rita Ferreira, João Carlos Rodrigues, Daniela Santos, Sílvia Duarte, Luís Vieira, Ângela S. Inácio, Henrique Carrêlo, Winchil L.C. Vaz, João Paulo Gomes, Alexandra Nunes, João Conde, Otilia V. Vieira

Resultado de pesquisarevisão de pares

1 Citação (Scopus)

Resumo

Sexually transmitted infections and urogenital-perinatal infections are significant health challenges owing to their asymptomatic nature, multidrug-resistant pathogens, and lack of effective vaccines. Surfactants are under investigation as potential antimicrobial agents and alternatives to traditional antibiotics. Here, we discovered that N-dodecylpyridinium bromide (C12PB), a cationic quaternary ammonium surfactant, has very low potential to induce antimicrobial resistance with no antibiotic cross-resistance or inflammation in vitro. Therefore, we developed a preclinical antibiotic-free cationic surfactant-based cellulose hydrogel for treating sexually transmitted infections. The C12PB-hydrogels provided sustained surfactant release, enhancing their biocompatibility and antibacterial activity without inflammation or epithelial disruption of the vaginal tract. In a preclinical model of Neisseria gonorrhoeae infection, a single application of the C12PB-hydrogel showed a 2- to 3-fold reduction in infection. This lays the foundation for the future development of C12PB-hydrogels for sexually transmitted infections, demonstrating potent antibacterial activity and minimal risk of antimicrobial resistance or inflammation.

Idioma originalInglês
Páginas (de-até)2205-2235
Número de páginas31
RevistaMatter
Volume7
Número de emissão6
DOIs
Estado da publicaçãoPublicadas - 1 jun. 2024

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© 2024 Elsevier Inc.

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