TY - JOUR
T1 - Obesity and Cancer
T2 - the Profile of a Population who Underwent Bariatric Surgery
AU - CRIO group
AU - Brito, Helena
AU - Santos, Ana C.
AU - Preto, John
AU - Carvalho, Davide
AU - Freitas, Paula
AU - Varela, Ana
AU - Pinho, André
AU - Galego, Carla
AU - Gil, Cidália
AU - Martins, Cristina
AU - Melim, Diva
AU - da Costa, Eduardo Lima
AU - Pinto, Eduardo
AU - Lau, Eva
AU - Correia, Flora
AU - Sousa, Hugo
AU - Magalhães, Inês
AU - Brandão, Isabel
AU - Pereira, Luís Miguel
AU - Silva, Marco
AU - Nunes, Patrícia
AU - Souto, Selma
AU - Andrade, Sertório Manuel
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/11
Y1 - 2021/11
N2 - Introduction: Obesity is a significant risk factor for cancer incidence and mortality. The number of patients with obesity who undergo bariatric surgery is increasing; however, the impact of such a procedure in affecting the risk of cancer is not completely understood yet. Methods: We conducted a retrospective unicentric cohort study to characterize the occurrence of cancer in patients who underwent bariatric surgery from January 2010 to December 2018. For cases of cancer identified after bariatric surgery, we performed a cancer-free survival analysis over time. We also performed a cross-sectional analysis of demographic and clinical characteristics at the time of surgery and compared patients with or without a cancer diagnosis. Results: Of the 2578 patients who underwent bariatric surgery, 117 patients (4.5%) were diagnosed with a cancer. Fifty-nine cases were diagnosed before surgery, and the remaining 58 cases occurred after the bariatric procedure. The prevalence of cancer was more accentuated in women (4.9%) than among men (2.7%). Thyroid and breast cancer were the most frequent before and after bariatric surgery, respectively. On average, patients with cancer diagnosis were older (49.0 vs 43.3 years, p<0.001) and with a lower level of education (7.4 vs 8.6 school years, p=0.002). Conclusion: Almost all the cases of cancer identified in this study were obesity-related cancers. Further prospective studies are needed to extend the current knowledge regarding the cancer risk profile of patients who undergo bariatric surgery.
AB - Introduction: Obesity is a significant risk factor for cancer incidence and mortality. The number of patients with obesity who undergo bariatric surgery is increasing; however, the impact of such a procedure in affecting the risk of cancer is not completely understood yet. Methods: We conducted a retrospective unicentric cohort study to characterize the occurrence of cancer in patients who underwent bariatric surgery from January 2010 to December 2018. For cases of cancer identified after bariatric surgery, we performed a cancer-free survival analysis over time. We also performed a cross-sectional analysis of demographic and clinical characteristics at the time of surgery and compared patients with or without a cancer diagnosis. Results: Of the 2578 patients who underwent bariatric surgery, 117 patients (4.5%) were diagnosed with a cancer. Fifty-nine cases were diagnosed before surgery, and the remaining 58 cases occurred after the bariatric procedure. The prevalence of cancer was more accentuated in women (4.9%) than among men (2.7%). Thyroid and breast cancer were the most frequent before and after bariatric surgery, respectively. On average, patients with cancer diagnosis were older (49.0 vs 43.3 years, p<0.001) and with a lower level of education (7.4 vs 8.6 school years, p=0.002). Conclusion: Almost all the cases of cancer identified in this study were obesity-related cancers. Further prospective studies are needed to extend the current knowledge regarding the cancer risk profile of patients who undergo bariatric surgery.
KW - Bariatric surgery
KW - Cancer
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85112579826&partnerID=8YFLogxK
U2 - 10.1007/s11695-021-05626-0
DO - 10.1007/s11695-021-05626-0
M3 - Article
C2 - 34370161
AN - SCOPUS:85112579826
SN - 0960-8923
VL - 31
SP - 4682
EP - 4691
JO - Obesity Surgery
JF - Obesity Surgery
IS - 11
ER -