Neuropsychiatric Symptoms are Related to Blood-biomarkers in Major Neurocognitive Disorders

Inês Marques-Aleixo, Arnaldina Sampaio, Lucimére Bohn, Flavia Machado, Duarte Barros, Oscár Ribeiro, Joana Carvalho, José Magalhães

Resultado de pesquisarevisão de pares

1 Citação (Scopus)

Resumo

Background: Neuropsychiatric symptoms (NPS) are highly prevalent among individuals with major neurocognitive disorders (MNCD). Objective: Here, we characterized blood biomarkers (metabolic, inflammatory, neurotrophic profiles and total antioxidant), body composition, physical fitness and quality of life (QoL) in individuals with MNCD according to NPS. Methods: The sample comprised 34 older adults (71.4% women; 74.06±6.03 yrs, with MNCD diag-nosis) categorized according to 50th percentile [Low (≤12) or High (≥13)] for NPS (Neuropsychiatric Inventory Questionnaire). Sociodemographic, clinical data, body composition, anthropometric, cognitive assessment (ADAS-Cog), physical fitness (Senior Fitness Test), QoL (QoL-Alzheimer’s Disease scale) were evaluated, and blood samples were collected for biochemical analysis. Results: Low compared to high NPS group showed higher levels of IL-6, IGF-1and neurotrophic z-score (composite of IGF-1, VEGF-1, BDNF). Additionally, low compared to high NPS group have higher QoL, aerobic fitness and upper body and lower body strength. Conclusion: The severity of NPS seems to be related to modified neurotrophic and inflammatory outcomes, lower physical fitness, and poor QoL. Strategies to counteract NPS development may preserve the physical and mental health of individuals with MNCD.

Idioma originalInglês
Páginas (de-até)74-84
Número de páginas11
RevistaCurrent Aging Science
Volume17
Número de emissão1
DOIs
Estado da publicaçãoPublicadas - 1 mar. 2024

Nota bibliográfica

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Financiamento

Financiadoras/-esNúmero do financiador
ITR
Laboratory for Integrative and Translational Research in Population HealthLA/P/0064/2020, SFRH/BD/136635/2018, 2020.05911, POCI-01-0145-FEDER-031808
Fundação para a Ciência e TecnologiaFCT/UIDB/00617/2020

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