TY - JOUR
T1 - Neuropsychiatric Symptoms are Related to Blood-biomarkers in Major Neurocognitive Disorders
AU - Marques-Aleixo, Inês
AU - Sampaio, Arnaldina
AU - Bohn, Lucimére
AU - Machado, Flavia
AU - Barros, Duarte
AU - Ribeiro, Oscár
AU - Carvalho, Joana
AU - Magalhães, José
N1 - Copyright© Bentham Science Publishers; For any queries, please email at [email protected].
PY - 2024/3/1
Y1 - 2024/3/1
N2 - Background: Neuropsychiatric symptoms (NPS) are highly prevalent among individuals with major neurocognitive disorders (MNCD). Objective: Here, we characterized blood biomarkers (metabolic, inflammatory, neurotrophic profiles and total antioxidant), body composition, physical fitness and quality of life (QoL) in individuals with MNCD according to NPS. Methods: The sample comprised 34 older adults (71.4% women; 74.06±6.03 yrs, with MNCD diag-nosis) categorized according to 50th percentile [Low (≤12) or High (≥13)] for NPS (Neuropsychiatric Inventory Questionnaire). Sociodemographic, clinical data, body composition, anthropometric, cognitive assessment (ADAS-Cog), physical fitness (Senior Fitness Test), QoL (QoL-Alzheimer’s Disease scale) were evaluated, and blood samples were collected for biochemical analysis. Results: Low compared to high NPS group showed higher levels of IL-6, IGF-1and neurotrophic z-score (composite of IGF-1, VEGF-1, BDNF). Additionally, low compared to high NPS group have higher QoL, aerobic fitness and upper body and lower body strength. Conclusion: The severity of NPS seems to be related to modified neurotrophic and inflammatory outcomes, lower physical fitness, and poor QoL. Strategies to counteract NPS development may preserve the physical and mental health of individuals with MNCD.
AB - Background: Neuropsychiatric symptoms (NPS) are highly prevalent among individuals with major neurocognitive disorders (MNCD). Objective: Here, we characterized blood biomarkers (metabolic, inflammatory, neurotrophic profiles and total antioxidant), body composition, physical fitness and quality of life (QoL) in individuals with MNCD according to NPS. Methods: The sample comprised 34 older adults (71.4% women; 74.06±6.03 yrs, with MNCD diag-nosis) categorized according to 50th percentile [Low (≤12) or High (≥13)] for NPS (Neuropsychiatric Inventory Questionnaire). Sociodemographic, clinical data, body composition, anthropometric, cognitive assessment (ADAS-Cog), physical fitness (Senior Fitness Test), QoL (QoL-Alzheimer’s Disease scale) were evaluated, and blood samples were collected for biochemical analysis. Results: Low compared to high NPS group showed higher levels of IL-6, IGF-1and neurotrophic z-score (composite of IGF-1, VEGF-1, BDNF). Additionally, low compared to high NPS group have higher QoL, aerobic fitness and upper body and lower body strength. Conclusion: The severity of NPS seems to be related to modified neurotrophic and inflammatory outcomes, lower physical fitness, and poor QoL. Strategies to counteract NPS development may preserve the physical and mental health of individuals with MNCD.
KW - Age Factors
KW - Aged
KW - Aged, 80 and over
KW - Biomarkers/blood
KW - Body Composition
KW - Brain-Derived Neurotrophic Factor/blood
KW - Cognition
KW - Cross-Sectional Studies
KW - Female
KW - Humans
KW - Inflammation Mediators/blood
KW - Insulin-Like Growth Factor I/metabolism
KW - Interleukin-6/blood
KW - Male
KW - Mental Health
KW - Neurocognitive Disorders/blood
KW - Neuropsychological Tests
KW - Physical Fitness
KW - Quality of Life
KW - Severity of Illness Index
KW - Vascular Endothelial Growth Factor A/blood
UR - http://www.scopus.com/inward/record.url?scp=85187177897&partnerID=8YFLogxK
U2 - 10.2174/1874609816666230816090934
DO - 10.2174/1874609816666230816090934
M3 - Article
C2 - 37904566
AN - SCOPUS:85187177897
SN - 1874-6098
VL - 17
SP - 74
EP - 84
JO - Current Aging Science
JF - Current Aging Science
IS - 1
ER -