TY - JOUR
T1 - Microlitre/millilitre shaken bioreactors in fermentative and biotransformation processes - A review
AU - Fernandes, P.
AU - Cabral, J. M.S.
PY - 2006/7
Y1 - 2006/7
N2 - The use of small-scale vessels (below 100 mL) as tools for the characterization of fermentative and biotransformation processes is an emergent approach, which may provide a wide array of data with significant time and cost savings. These result from the reduced reagent requirements and the possibility of simultaneously carrying out the evaluation of multiple operational parameters and assessing their individual or combined effect in the process. Furthermore, it is envisaged that such data will provide the basis for a rational scale-up of the systems evaluated. This requires an engineering approach, which has been integrated with the development of microscale technology. This review comprises recent findings related to the use and characterization of Erlenmeyer type flasks, test tubes and microtiter plates as bioreactors.
AB - The use of small-scale vessels (below 100 mL) as tools for the characterization of fermentative and biotransformation processes is an emergent approach, which may provide a wide array of data with significant time and cost savings. These result from the reduced reagent requirements and the possibility of simultaneously carrying out the evaluation of multiple operational parameters and assessing their individual or combined effect in the process. Furthermore, it is envisaged that such data will provide the basis for a rational scale-up of the systems evaluated. This requires an engineering approach, which has been integrated with the development of microscale technology. This review comprises recent findings related to the use and characterization of Erlenmeyer type flasks, test tubes and microtiter plates as bioreactors.
KW - Mass-transfer correlations
KW - Monitoring and control
KW - Predictive models
KW - Small-scale bioreactors
UR - http://www.scopus.com/inward/record.url?scp=33747343757&partnerID=8YFLogxK
U2 - 10.1080/10242420600667684
DO - 10.1080/10242420600667684
M3 - Review article
AN - SCOPUS:33747343757
SN - 1024-2422
VL - 24
SP - 237
EP - 252
JO - Biocatalysis and Biotransformation
JF - Biocatalysis and Biotransformation
IS - 4
ER -