TY - JOUR
T1 - Exercise is medicine
T2 - a new perspective for health promotion in bipolar disorder
AU - Sá Filho, Alberto Souza
AU - Cheniaux, Elie
AU - de Paula, Carolina Cavalcante
AU - Murillo-Rodriguez, Eric
AU - Teixeira, Diogo
AU - Monteiro, Diogo
AU - Cid, Luis
AU - Yamamoto, Tetsuya
AU - Telles-Correia, Diogo
AU - Imperatori, Claudio
AU - Budde, Henning
AU - Machado, Sergio
N1 - Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020/11
Y1 - 2020/11
N2 - Introduction: Similar effects in reducing the symptoms of the mood disorder are reported in the literature compared the action of drugs and aerobic exercise sessions, demonstrating the potential of exercise in the control and mood stabilization. Therefore, there are many reasons to believe that the increased cardiorespiratory fitness (VO2max) can be an important means of protection and a reducing potential of physical and mental damage in bipolar disorders (BD). This review will highlight the current pattern of response of exercise on the pathophysiology of BD, relating the possible mechanisms, and hypotheses based on exercises. Areas covered: The mechanism of monoaminergic action and its relationship with exercise, role of physical conditioning and increased VO2Max on neurotrophin release, and new perspectives on long-term exercise will be reviewed. Expert opinion: The adaptations to training, although little explored in the context of BD, can induce the expression of substances that co-regulate several processes related to the pathophysiology of BD. Furthermore, high intensity interval training (HIIT) can also be adjusted to improve the physical fitness and health in patients with BD. Future research is needed to adopt a training strategy that is both time efficient and adequate for the population in question.
AB - Introduction: Similar effects in reducing the symptoms of the mood disorder are reported in the literature compared the action of drugs and aerobic exercise sessions, demonstrating the potential of exercise in the control and mood stabilization. Therefore, there are many reasons to believe that the increased cardiorespiratory fitness (VO2max) can be an important means of protection and a reducing potential of physical and mental damage in bipolar disorders (BD). This review will highlight the current pattern of response of exercise on the pathophysiology of BD, relating the possible mechanisms, and hypotheses based on exercises. Areas covered: The mechanism of monoaminergic action and its relationship with exercise, role of physical conditioning and increased VO2Max on neurotrophin release, and new perspectives on long-term exercise will be reviewed. Expert opinion: The adaptations to training, although little explored in the context of BD, can induce the expression of substances that co-regulate several processes related to the pathophysiology of BD. Furthermore, high intensity interval training (HIIT) can also be adjusted to improve the physical fitness and health in patients with BD. Future research is needed to adopt a training strategy that is both time efficient and adequate for the population in question.
KW - Bipolar disorder
KW - catecholamines
KW - exercise
KW - high intensity interval training
KW - monoaminergic system
UR - http://www.scopus.com/inward/record.url?scp=85089996322&partnerID=8YFLogxK
U2 - 10.1080/14737175.2020.1807329
DO - 10.1080/14737175.2020.1807329
M3 - Review article
C2 - 32762382
AN - SCOPUS:85089996322
SN - 1473-7175
VL - 20
SP - 1099
EP - 1107
JO - Expert Review of Neurotherapeutics
JF - Expert Review of Neurotherapeutics
IS - 11
ER -