Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles: Structural Studies and Chemical Modification

Catarina García; Carlos E.S. Bernardes; M. Fátima M. Piedade; Gaia Fumagalli; Eleonora Colombo; Ana M. Díaz-Lanza; Catarina P. Reis; Isabel Correia; Lia Ascensão; Daniele Passarella; Manuel E.Minas Da Piedade; Patrícia Rijo

doi:10.1021/acsomega.2c05353

Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles: Structural Studies and Chemical Modification

Catarina García, Carlos E.S. Bernardes, M. Fátima M. Piedade, Gaia Fumagalli, Eleonora Colombo, Ana M. Díaz-Lanza, Catarina P. Reis, Isabel Correia, Lia Ascensão, Daniele Passarella, Manuel E.Minas Da Piedade, Patrícia Rijo

CBIOS - Centro de Investigação em Biociências e Tecnologias da Saúde

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Resumo

6,7-Dehydroroyleanone (DHR) is a caspase-induced cytotoxic abietane diterpene, frequently found on Plectranthus spp. A pharmaceutical formulation consisting of a DHR-squalene conjugate was synthesized and analyzed by different techniques such as scanning electron microscopy (SEM). The facile production of the dispersion of DHR-squalene conjugate nanoparticles in phosphate buffer (pH 7.4) suggests that this nanodelivery platform may be an effective system to improve the solubility and bioavailability of DHR, so that therapeutical systemic levels may be achieved.

Idioma original	Inglês
Páginas (de-até)	44180-44186
Número de páginas	7
Revista	ACS Omega
Volume	7
Número de emissão	48
DOIs	https://doi.org/10.1021/acsomega.2c05353
Estado da publicação	Publicadas - 6 dez. 2022

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Publisher Copyright:
© 2022 The Authors. Published by American Chemical Society.

Financiamento

Financiadoras/-es	Número do financiador
Fundação para a Ciência e a Tecnologia	2021.03239, UIDP/04567/2020, LISBOA-01-0145-FEDER-028401, PTDC/QUI-OUT/28401/2017, UIDB/00100/2020, UIDB/04567/2020, UIDP/00100/2020, UIDB/04138/2020, UIDP/04138/2020

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10.1021/acsomega.2c05353

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García, C., Bernardes, C. E. S., Piedade, M. F. M., Fumagalli, G., Colombo, E., Díaz-Lanza, A. M., Reis, C. P., Correia, I., Ascensão, L., Passarella, D., Da Piedade, M. E. M., & Rijo, P. (2022). Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles: Structural Studies and Chemical Modification. ACS Omega, 7(48), 44180-44186. https://doi.org/10.1021/acsomega.2c05353

@article{b96d66c1e5284f7a8e573b1c1c4d91c5,

title = "Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles: Structural Studies and Chemical Modification",

abstract = "6,7-Dehydroroyleanone (DHR) is a caspase-induced cytotoxic abietane diterpene, frequently found on Plectranthus spp. A pharmaceutical formulation consisting of a DHR-squalene conjugate was synthesized and analyzed by different techniques such as scanning electron microscopy (SEM). The facile production of the dispersion of DHR-squalene conjugate nanoparticles in phosphate buffer (pH 7.4) suggests that this nanodelivery platform may be an effective system to improve the solubility and bioavailability of DHR, so that therapeutical systemic levels may be achieved.",

author = "Catarina Garc{\'i}a and Bernardes, {Carlos E.S.} and Piedade, {M. F{\'a}tima M.} and Gaia Fumagalli and Eleonora Colombo and D{\'i}az-Lanza, {Ana M.} and Reis, {Catarina P.} and Isabel Correia and Lia Ascens{\~a}o and Daniele Passarella and {Da Piedade}, {Manuel E.Minas} and Patr{\'i}cia Rijo",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Published by American Chemical Society.",

year = "2022",

month = dec,

day = "6",

doi = "10.1021/acsomega.2c05353",

language = "English",

volume = "7",

pages = "44180--44186",

journal = "ACS Omega",

issn = "2470-1343",

publisher = "American Chemical Society",

number = "48",

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García, C, Bernardes, CES, Piedade, MFM, Fumagalli, G, Colombo, E, Díaz-Lanza, AM, Reis, CP, Correia, I, Ascensão, L, Passarella, D, Da Piedade, MEM & Rijo, P 2022, 'Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles: Structural Studies and Chemical Modification', ACS Omega, vol. 7, n.º 48, pp. 44180-44186. https://doi.org/10.1021/acsomega.2c05353

TY - JOUR

T1 - Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles

T2 - Structural Studies and Chemical Modification

AU - García, Catarina

AU - Bernardes, Carlos E.S.

AU - Piedade, M. Fátima M.

AU - Fumagalli, Gaia

AU - Colombo, Eleonora

AU - Díaz-Lanza, Ana M.

AU - Reis, Catarina P.

AU - Correia, Isabel

AU - Ascensão, Lia

AU - Passarella, Daniele

AU - Da Piedade, Manuel E.Minas

AU - Rijo, Patrícia

PY - 2022/12/6

Y1 - 2022/12/6

N2 - 6,7-Dehydroroyleanone (DHR) is a caspase-induced cytotoxic abietane diterpene, frequently found on Plectranthus spp. A pharmaceutical formulation consisting of a DHR-squalene conjugate was synthesized and analyzed by different techniques such as scanning electron microscopy (SEM). The facile production of the dispersion of DHR-squalene conjugate nanoparticles in phosphate buffer (pH 7.4) suggests that this nanodelivery platform may be an effective system to improve the solubility and bioavailability of DHR, so that therapeutical systemic levels may be achieved.

AB - 6,7-Dehydroroyleanone (DHR) is a caspase-induced cytotoxic abietane diterpene, frequently found on Plectranthus spp. A pharmaceutical formulation consisting of a DHR-squalene conjugate was synthesized and analyzed by different techniques such as scanning electron microscopy (SEM). The facile production of the dispersion of DHR-squalene conjugate nanoparticles in phosphate buffer (pH 7.4) suggests that this nanodelivery platform may be an effective system to improve the solubility and bioavailability of DHR, so that therapeutical systemic levels may be achieved.

UR - http://www.scopus.com/inward/record.url?scp=85143085629&partnerID=8YFLogxK

U2 - 10.1021/acsomega.2c05353

DO - 10.1021/acsomega.2c05353

M3 - Article

AN - SCOPUS:85143085629

SN - 2470-1343

VL - 7

SP - 44180

EP - 44186

JO - ACS Omega

JF - ACS Omega

IS - 48

ER -

Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles: Structural Studies and Chemical Modification

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