Short-chain fatty acids: A link between prebiotics and microbiota in chronic kidney disease

Marta Esgalhado; Julie A. Kemp; Nagila R.T. Damasceno; Denis Fouque; Denise Mafra

doi:10.2217/fmb-2017-0059

Short-chain fatty acids: A link between prebiotics and microbiota in chronic kidney disease

Marta Esgalhado
, Julie A. Kemp
, Nagila R.T. Damasceno
, Denis Fouque
, Denise Mafra

Universidade Federal Fluminense
Universidade de São Paulo
Universite Claude Bernard Lyon 1

Research output: Contribution to journal › Review article › peer-review

69 Citations (Scopus)

Abstract

Under physiologic conditions, the human gut microbiota performs several activities essential to the body health. In contrast, their imbalances exacerbate some actions which can promote a cascade of metabolic abnormalities, and vice versa. Numerous diseases, including chronic kidney disease, are associated with gut microbiota imbalance, and among several strategies to re-establish gut symbiosis, prebiotics seem to represent an effective nonpharmacological approach. Prebiotics fermentation by gut microbiota produce short-chain fatty acids, which improve the gut barrier integrity and function, and modulate the glucose and lipid metabolism as well as the inflammatory response and immune system. Therefore, this literature review intends to discuss the beneficial effects of prebiotics in human health through short-chain fatty acids production, with a particular interest on chronic kidney disease.

Original language	English
Pages (from-to)	1413-1425
Number of pages	13
Journal	Future Microbiology
Volume	12
Issue number	15
DOIs	https://doi.org/10.2217/fmb-2017-0059
Publication status	Published - 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 Future Medicine Ltd.

Funding

The authors would like to thank Coordenac¸ão de Aperfeic¸oamento de Pessoal de Nível Superior (CAPES), Fundac¸ão de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). The authors would like to thank Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

Funders
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chronic kidney disease
Gut microbiota
Prebiotic
Short-chain fatty acids

Access to Document

10.2217/fmb-2017-0059

Cite this

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title = "Short-chain fatty acids: A link between prebiotics and microbiota in chronic kidney disease",

abstract = "Under physiologic conditions, the human gut microbiota performs several activities essential to the body health. In contrast, their imbalances exacerbate some actions which can promote a cascade of metabolic abnormalities, and vice versa. Numerous diseases, including chronic kidney disease, are associated with gut microbiota imbalance, and among several strategies to re-establish gut symbiosis, prebiotics seem to represent an effective nonpharmacological approach. Prebiotics fermentation by gut microbiota produce short-chain fatty acids, which improve the gut barrier integrity and function, and modulate the glucose and lipid metabolism as well as the inflammatory response and immune system. Therefore, this literature review intends to discuss the beneficial effects of prebiotics in human health through short-chain fatty acids production, with a particular interest on chronic kidney disease.",

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author = "Marta Esgalhado and Kemp, \{Julie A.\} and Damasceno, \{Nagila R.T.\} and Denis Fouque and Denise Mafra",

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year = "2017",

doi = "10.2217/fmb-2017-0059",

language = "English",

volume = "12",

pages = "1413--1425",

journal = "Future Microbiology",

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TY - JOUR

T1 - Short-chain fatty acids

T2 - A link between prebiotics and microbiota in chronic kidney disease

AU - Esgalhado, Marta

AU - Kemp, Julie A.

AU - Damasceno, Nagila R.T.

AU - Fouque, Denis

AU - Mafra, Denise

PY - 2017

Y1 - 2017

N2 - Under physiologic conditions, the human gut microbiota performs several activities essential to the body health. In contrast, their imbalances exacerbate some actions which can promote a cascade of metabolic abnormalities, and vice versa. Numerous diseases, including chronic kidney disease, are associated with gut microbiota imbalance, and among several strategies to re-establish gut symbiosis, prebiotics seem to represent an effective nonpharmacological approach. Prebiotics fermentation by gut microbiota produce short-chain fatty acids, which improve the gut barrier integrity and function, and modulate the glucose and lipid metabolism as well as the inflammatory response and immune system. Therefore, this literature review intends to discuss the beneficial effects of prebiotics in human health through short-chain fatty acids production, with a particular interest on chronic kidney disease.

AB - Under physiologic conditions, the human gut microbiota performs several activities essential to the body health. In contrast, their imbalances exacerbate some actions which can promote a cascade of metabolic abnormalities, and vice versa. Numerous diseases, including chronic kidney disease, are associated with gut microbiota imbalance, and among several strategies to re-establish gut symbiosis, prebiotics seem to represent an effective nonpharmacological approach. Prebiotics fermentation by gut microbiota produce short-chain fatty acids, which improve the gut barrier integrity and function, and modulate the glucose and lipid metabolism as well as the inflammatory response and immune system. Therefore, this literature review intends to discuss the beneficial effects of prebiotics in human health through short-chain fatty acids production, with a particular interest on chronic kidney disease.

KW - Chronic kidney disease

KW - Gut microbiota

KW - Prebiotic

KW - Short-chain fatty acids

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DO - 10.2217/fmb-2017-0059

M3 - Review article

C2 - 29027814

AN - SCOPUS:85044187845

SN - 1746-0913

VL - 12

SP - 1413

EP - 1425

JO - Future Microbiology

JF - Future Microbiology

IS - 15

ER -

Short-chain fatty acids: A link between prebiotics and microbiota in chronic kidney disease

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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