P-glycoprotein and membrane roles in multidrug resistance

Ricardo J. Ferreira, Daniel Jva Dos Santos, Maria Jose U. Ferreira

Research output: Contribution to journalReview articlepeer-review

69 Citations (Scopus)

Abstract

Multidrug-resistance (MDR) phenomena are a worldwide health concern. ATP-binding cassette efflux pumps as P-glycoprotein have been thoroughly studied in a frantic run to develop new efflux modulators capable to reverse MDR phenotypes. The study of efflux pumps has provided some key aspects on drug extrusion, however the answers could not be found solely on ATP-binding cassette transporters. Its counterpart-the plasma membrane-is now emerging as a critical structure able to modify drug behavior and efflux pump activity. Alterations in the membrane surrounding P-glycoprotein are now known to modulate drug efflux, with membrane-related biophysical, biochemical and mechanical aspects further increasing the complexity of an already multifaceted phenomena. This review summarizes the main knowledge comprising the plasma membrane role in MDR.

Original languageEnglish
Pages (from-to)929-946
Number of pages18
JournalFuture Medicinal Chemistry
Volume7
Issue number7
DOIs
Publication statusPublished - 1 Jun 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Future Science Ltd.

Fingerprint

Dive into the research topics of 'P-glycoprotein and membrane roles in multidrug resistance'. Together they form a unique fingerprint.

Cite this