Abstract
The use of functional excipients such as ionic liquids (ILs) and the encapsulation of drugs into nanocarriers are useful strategies to overcome poor drug solubility. The aim of this work was to evaluate the potential of IL-polymer nanoparticle hybrid systems as tools to deliver poorly soluble drugs. These systems were obtained using a methodology previously developed by our group and improved herein to produce IL-polymer nanoparticle hybrid systems. Two different choline-based ILs and poly (lactic-co-glycolic acid) (PLGA) 50:50 or PLGA 75:25 were used to load rutin into the delivery system. The resulting rutin-loaded IL-polymer nanoparticle hybrid systems presented a diameter of 250–300 nm, with a low polydispersity index and a zeta potential of about −40 mV. The drug association efficiency ranged from 51% to 76%, which represents a good achievement considering the poor solubility of rutin. No significant particle aggregation was obtained upon freeze-drying. The presence of the IL in the nanosystem does not affect its sustained release properties, achieving about 85% of rutin released after 72 h. The cytotoxicity studies showed that the delivery system was not toxic to HaCat cells. Our findings may open a new paradigm on the therapy improvement of diseases treated with poorly soluble drugs.
| Original language | English |
|---|---|
| Article number | 1148 |
| Journal | Nanomaterials |
| Volume | 9 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2019 |
Bibliographical note
Publisher Copyright:© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Funding
This work was financed by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operational Programme for Competitiveness and Internationalization (POCI), and by Portuguese funds through FCT—Fundação para a Ciência e a Tecnologia (FCT) in the framework of the project POCI-01-0145-FEDER-032610—PTDC/MEC-DER/32610/2017. It was also supported by FCT under the projects UID/DTP/04567/2019 and UID/DTP/04567/2016. Ana Júlio and Rita Caparica would like to thank ALIES, Portugal for the grant PADDIC 2018-2019. The authors gratefully thank Professor André Rolim Baby, from the School of Pharmaceutical Sciences of the University of São Paulo, for providing rutin.
| Funders | Funder number |
|---|---|
| Programa Operacional Temático Factores de Competitividade | |
| European Regional Development Fund | |
| School of Pharmaceutical Sciences of the University of São Paulo | |
| Fundação para a Ciência e a Tecnologia | UID/DTP/04567/2019, PADDIC 2018-2019, POCI-01-0145-FEDER-032610—PTDC/MEC-DER/32610/2017, PTDC/MEC-DER/32610/2017, UID/DTP/04567/2016 |
Keywords
- Drug delivery
- Hybrid system
- Ionic liquid
- Nanoparticle
- PLGA
- Polymer
- Poorly soluble drug
- Rutin