Abstract
Poor drug solubility represents a major problem for the development of new drug delivery systems. Finding new
excipients that promote drug solubility is one of the strategies currently used. In this context, ionic liquids (ILs)
have been studied as solubility promoters due to their ability to be placed in either lipophilic or hydrophilic
solutions.
Two choline-based ILs, [Cho][Met] and [Cho][Cys], were prepared and their influence on the solubility of a model
hydrophilic drug, caffeine, was evaluated at 25 ºC.
Results show that both ILs improved drug solubility, with [Cho][Met] providing a higher soluble concentration.
Our results suggest that the studied choline-based ILs are effective solubility enhancers of caffeine and thus may
potentially be used as functional ingredients in drug delivery systems.
| Translated title of the contribution | Influence of two choline-based ionic liquids on the solubility of caffeine |
|---|---|
| Original language | Portuguese |
| Pages (from-to) | 96-102 |
| Journal | Biomedical and biopharmaceutical research : jornal de investigação biomédica e biofarmacêutica |
| Volume | 15 |
| Issue number | 1 |
| Publication status | Published - 2018 |
Bibliographical note
This work was financed by national funds through FCT - Foundation for Science and Technology, I.P., under the project UID/DTP/04567/2016. Part of the work was also supported by FCT to CQB through project UID/ MULTI/00612/2013. Ana Júlio acknowledges his research grant attributed in the scope of the project UID/ DTP/04567/2016.Keywords
- DRUGS