Abstract
We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.
| Original language | English |
|---|---|
| Pages (from-to) | 741-745 |
| Number of pages | 5 |
| Journal | Emerging Infectious Diseases |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2018 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2018, Centers for Disease Control and Prevention (CDC). All rights reserved.
Funding
This work was supported by the National Institute of Health Dr. This work was supported by the National Institute of Health Dr. Ricardo Jorge (grant no. 2016DDI1284). We also acknowledge grant Pest-C/EQB/LA0006/2011 from Fundação para a Ciência e a Tecnologia (FCT; http://www.fct.pt) and program Investigador FCT (IF/00268/2013/CP1173/CT0006 to M.S.). A.L.M. was supported by a PhD fellowship (PD/BD/105738/2014) from the FCT. Ricardo Jorge (grant no. 2016DDI1284). We also acknowledge grant Pest-C/EQB/LA0006/2011 from Fundação para a Ciência e a Tecnologia (FCT; http://www.fct.pt) and program Investigador FCT (IF/00268/2013/CP1173/CT0006 to M.S.). A.L.M. was supported by a PhD fellowship (PD/BD/105738/2014) from the FCT.
| Funders | Funder number |
|---|---|
| National Institute of Health | |
| National Institutes of Health | 2016DDI1284 |
| FCT - Fundação para a Ciência e a Tecnologia | IF/00268/2013/CP1173/CT0006, Pest-C/EQB/LA0006/2011, PD/BD/105738/2014 |
| Instituto Nacional de Ciência e Tecnologia para Excitotoxicidade e Neuroproteção |
