Imipenem resistance in Clostridium difficile ribotype 017, Portugal

Joana Isidro; Andrea Santos; Alexandra Nunes; Vítor Borges; Catarina Silva; Luís Vieira; Aristides L. Mendes; Mónica Serrano; Adriano O. Henriques; João Paulo Gomes; Mónica Oleastro

doi:10.3201/eid2404.170095

Imipenem resistance in Clostridium difficile ribotype 017, Portugal

Joana Isidro, Andrea Santos, Alexandra Nunes, Vítor Borges, Catarina Silva, Luís Vieira, Aristides L. Mendes, Mónica Serrano, Adriano O. Henriques, João Paulo Gomes, Mónica Oleastro

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.

Original language	English
Pages (from-to)	741-745
Number of pages	5
Journal	Emerging Infectious Diseases
Volume	24
Issue number	4
DOIs	https://doi.org/10.3201/eid2404.170095
Publication status	Published - Apr 2018
Externally published	Yes

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© 2018, Centers for Disease Control and Prevention (CDC). All rights reserved.

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title = "Imipenem resistance in Clostridium difficile ribotype 017, Portugal",

abstract = "We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.",

author = "Joana Isidro and Andrea Santos and Alexandra Nunes and V{\'i}tor Borges and Catarina Silva and Lu{\'i}s Vieira and Mendes, {Aristides L.} and M{\'o}nica Serrano and Henriques, {Adriano O.} and Gomes, {Jo{\~a}o Paulo} and M{\'o}nica Oleastro",

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doi = "10.3201/eid2404.170095",

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T1 - Imipenem resistance in Clostridium difficile ribotype 017, Portugal

AU - Isidro, Joana

AU - Santos, Andrea

AU - Nunes, Alexandra

AU - Borges, Vítor

AU - Silva, Catarina

AU - Vieira, Luís

AU - Mendes, Aristides L.

AU - Serrano, Mónica

AU - Henriques, Adriano O.

AU - Gomes, João Paulo

AU - Oleastro, Mónica

PY - 2018/4

Y1 - 2018/4

N2 - We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.

AB - We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.

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U2 - 10.3201/eid2404.170095

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EP - 745

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 4

ER -

Imipenem resistance in Clostridium difficile ribotype 017, Portugal

Abstract

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