Aryl Hydrocarbon Receptor Activation in Chronic Kidney Disease: Role of Uremic Toxins

Jessyca S. Brito; Natália A. Borges; Marta Esgalhado; DAngelo C. Magliano; Christophe O. Soulage; Denise Mafra

doi:10.1159/000476074

Aryl Hydrocarbon Receptor Activation in Chronic Kidney Disease: Role of Uremic Toxins

Jessyca S. Brito
, Natália A. Borges
, Marta Esgalhado
, DAngelo C. Magliano
, Christophe O. Soulage
, Denise Mafra

Cardiovascular Sciences Graduate Program
Medical Sciences Graduate Program
Biomedical InstituteFederal University Fluminense
Institut national des sciences appliquées Lyon

Research output: Contribution to journal › Review article › peer-review

72 Citations (Scopus)

Abstract

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in the expression of xenobiotic-metabolizing enzymes, inflammatory cytokines and adhesion molecules. Uremic toxins such as indoxyl sulfate and indole acetic acid are derived from tryptophan fermentation by gut microbiota; they accumulate in patients with chronic kidney disease (CKD) on haemodialysis and have recently emerged as potent ligands of AhR. Therefore, AhR can serve as a mediator in inflammation and cardiovascular diseases in these patients. This review discusses current data that support a link between AhR activation and uremic toxins from gut microbiota in CKD.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Nephron
Volume	137
Issue number	1
DOIs	https://doi.org/10.1159/000476074
Publication status	Published - 1 Aug 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 Karger AG, Basel.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aryl hydrocarbon receptor
Chronic kidney disease
Inflammation
Uremic toxins

Access to Document

10.1159/000476074

Cite this

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abstract = "The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in the expression of xenobiotic-metabolizing enzymes, inflammatory cytokines and adhesion molecules. Uremic toxins such as indoxyl sulfate and indole acetic acid are derived from tryptophan fermentation by gut microbiota; they accumulate in patients with chronic kidney disease (CKD) on haemodialysis and have recently emerged as potent ligands of AhR. Therefore, AhR can serve as a mediator in inflammation and cardiovascular diseases in these patients. This review discusses current data that support a link between AhR activation and uremic toxins from gut microbiota in CKD.",

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T1 - Aryl Hydrocarbon Receptor Activation in Chronic Kidney Disease

T2 - Role of Uremic Toxins

AU - Brito, Jessyca S.

AU - Borges, Natália A.

AU - Esgalhado, Marta

AU - Magliano, DAngelo C.

AU - Soulage, Christophe O.

AU - Mafra, Denise

PY - 2017/8/1

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N2 - The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in the expression of xenobiotic-metabolizing enzymes, inflammatory cytokines and adhesion molecules. Uremic toxins such as indoxyl sulfate and indole acetic acid are derived from tryptophan fermentation by gut microbiota; they accumulate in patients with chronic kidney disease (CKD) on haemodialysis and have recently emerged as potent ligands of AhR. Therefore, AhR can serve as a mediator in inflammation and cardiovascular diseases in these patients. This review discusses current data that support a link between AhR activation and uremic toxins from gut microbiota in CKD.

AB - The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in the expression of xenobiotic-metabolizing enzymes, inflammatory cytokines and adhesion molecules. Uremic toxins such as indoxyl sulfate and indole acetic acid are derived from tryptophan fermentation by gut microbiota; they accumulate in patients with chronic kidney disease (CKD) on haemodialysis and have recently emerged as potent ligands of AhR. Therefore, AhR can serve as a mediator in inflammation and cardiovascular diseases in these patients. This review discusses current data that support a link between AhR activation and uremic toxins from gut microbiota in CKD.

KW - Aryl hydrocarbon receptor

KW - Chronic kidney disease

KW - Inflammation

KW - Uremic toxins

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SN - 1660-8151

VL - 137

SP - 1

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IS - 1

ER -

Aryl Hydrocarbon Receptor Activation in Chronic Kidney Disease: Role of Uremic Toxins

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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