A Parameter Estimation Process for Improved Drug Infusion

Hugo Alonso; Teresa Mendonça; Paula Rocha

doi:10.1007/978-3-031-81724-3_14

A Parameter Estimation Process for Improved Drug Infusion

Hugo Alonso, Teresa Mendonça, Paula Rocha

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In this paper, we consider a reduced parameter (RP) model for the effect of the drug atracurium on the neuromuscular blockade (NMB) level of patients undergoing general anesthesia. We propose a generalization of a previously introduced parameter estimation process to obtain the patient dependent parameters of the RP model. Furthermore, we consider a reference tracking problem, where the objective is to force the NMB level of the patients to follow a constant reference, and suggest an open-loop control law based on the estimated RP model. It turns out that the application of the identification process requires choosing two values. In this context, we present an experimental study whose goal is to clarify how these choices impact on the results of the reference tracking problem.

Original language	English
Title of host publication	CONTROLO 2024 - Proceedings of the 16th APCA International Conference on Automatic Control and Soft Computing, 2024
Editors	Antonio Pedro Aguiar, Paula Rocha Malonek, Fernando A. C. C. Fontes, Roman Chertovskih, Vítor Hugo Pinto
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	140-150
Number of pages	11
ISBN (Print)	9783031817236
DOIs	https://doi.org/10.1007/978-3-031-81724-3_14
Publication status	Published - 2025
Event	16th APCA International Conference on Automatic Control and Soft Computing, CONTROLO 2024 - Porto, Portugal Duration: 17 Jul 2024 → 19 Jul 2024

Publication series

Name	Lecture Notes in Electrical Engineering
Volume	1325 LNEE
ISSN (Print)	1876-1100
ISSN (Electronic)	1876-1119

Conference

Conference	16th APCA International Conference on Automatic Control and Soft Computing, CONTROLO 2024
Country/Territory	Portugal
City	Porto
Period	17/07/24 → 19/07/24

Bibliographical note

Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

Funding

This work was partially supported by the Center for Research and Development in Mathematics and Applications (CIDMA) through the Portuguese Foundation for Science and Technology (FCT - Fundação para a Ciência e a Tecnologia), references UIDB/04106/2020 and UIDP/04106/2020 (https://doi.org/10.54499/UIDB/04106/2020 and https://doi.org/10.54499/UIDP/04106/2020). This work was also financially supported by national funds through the FCT/MCTES (PIDDAC), under the RELIABLE project PTDC/EEI-AUT/3522/2020 (DOI 10.54499/PTDC/EEI-AUT/3522/2020), the Associate Laboratory Advanced Production and Intelligent Systems - ARISE LA/P/0112/2020 (DOI 10.54499/LA/P/0112/2020) and the Base Funding (UIDB/00147/2020) and Programmatic Funding (UIDP/00147/2020) of the R&D Unit Center for Systems and Technologies - SYSTEC.

Funders	Funder number
Center for Research and Development in Mathematics and Applications
FCT - Fundação para a Ciência e a Tecnologia	UIDB/04106/2020, UIDP/04106/2020

Keywords

Atracurium
Neuromuscular blockade
Open-loop control
Parameter estimation
Reduced parameter model

Access to Document

10.1007/978-3-031-81724-3_14

Cite this

Alonso, H., Mendonça, T., & Rocha, P. (2025). A Parameter Estimation Process for Improved Drug Infusion. In A. P. Aguiar, P. Rocha Malonek, F. A. C. C. Fontes, R. Chertovskih, & V. H. Pinto (Eds.), CONTROLO 2024 - Proceedings of the 16th APCA International Conference on Automatic Control and Soft Computing, 2024 (pp. 140-150). (Lecture Notes in Electrical Engineering; Vol. 1325 LNEE). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-031-81724-3_14

Alonso, Hugo ; Mendonça, Teresa ; Rocha, Paula. / A Parameter Estimation Process for Improved Drug Infusion. CONTROLO 2024 - Proceedings of the 16th APCA International Conference on Automatic Control and Soft Computing, 2024. editor / Antonio Pedro Aguiar ; Paula Rocha Malonek ; Fernando A. C. C. Fontes ; Roman Chertovskih ; Vítor Hugo Pinto. Springer Science and Business Media Deutschland GmbH, 2025. pp. 140-150 (Lecture Notes in Electrical Engineering).

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Alonso, H, Mendonça, T & Rocha, P 2025, A Parameter Estimation Process for Improved Drug Infusion. in AP Aguiar, P Rocha Malonek, FACC Fontes, R Chertovskih & VH Pinto (eds), CONTROLO 2024 - Proceedings of the 16th APCA International Conference on Automatic Control and Soft Computing, 2024. Lecture Notes in Electrical Engineering, vol. 1325 LNEE, Springer Science and Business Media Deutschland GmbH, pp. 140-150, 16th APCA International Conference on Automatic Control and Soft Computing, CONTROLO 2024, Porto, Portugal, 17/07/24. https://doi.org/10.1007/978-3-031-81724-3_14

A Parameter Estimation Process for Improved Drug Infusion. / Alonso, Hugo; Mendonça, Teresa; Rocha, Paula.
CONTROLO 2024 - Proceedings of the 16th APCA International Conference on Automatic Control and Soft Computing, 2024. ed. / Antonio Pedro Aguiar; Paula Rocha Malonek; Fernando A. C. C. Fontes; Roman Chertovskih; Vítor Hugo Pinto. Springer Science and Business Media Deutschland GmbH, 2025. p. 140-150 (Lecture Notes in Electrical Engineering; Vol. 1325 LNEE).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Alonso H, Mendonça T, Rocha P. A Parameter Estimation Process for Improved Drug Infusion. In Aguiar AP, Rocha Malonek P, Fontes FACC, Chertovskih R, Pinto VH, editors, CONTROLO 2024 - Proceedings of the 16th APCA International Conference on Automatic Control and Soft Computing, 2024. Springer Science and Business Media Deutschland GmbH. 2025. p. 140-150. (Lecture Notes in Electrical Engineering). doi: 10.1007/978-3-031-81724-3_14