Establishment of safety properties and clinical efficacy of rosmarinic acid in Quality by design (QbD) -optimized dermocosmetic formulations

The project was based on the application of the concepts of quality by design (QbD) and process analytical technology (PAT – Process Analytical Technology) to evaluate critical quality parameters and develop an optimized cosmetic formulation with rosmarinic acid. The formulations were developed using a factorial experimental design (DoE – Design of Experiments), characterized physically and physicochemically and evaluated for in vitro antioxidant activity and in vitro photoprotective efficacy, as well as for photostability. The formulations were also characterized for their photoprotective efficacy in vivo, as well as evaluated for their safety.