Antilipoperoxidative and anti-inflammatory effects of multifunctional sunscreens containing ferulic acid

Skin cancer is the most diagnosed type of cancer in the world, with excessive exposure to ultraviolet (UV) radiation from the Sun being its main cause. Oxidative stress, one of the factors responsible for the development of carcinomas, is also associated with frequent exposure to UV radiation. The use of photoprotective formulations is the most effective measure to protect against the malignant effects of this type of radiation. In addition to containing elements that absorb and/or reflect them, they also contain components that can help with skin homeostasis, such as antioxidant agents. In this study, ferulic acid, a natural compound recognized as a potential antioxidant, was used, together with two solar filters, bemotrizinol and octyl triazone, to carry out biosafety and efficacy methods, with the aim of improving techniques, in addition to a better elucidation of the effects of ferulic acid. In vivo, in vitro and ex vivo techniques were used to characterize elements such as inflammatory potential, antioxidative potential, molecule permeability and hydration.