Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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A computationally assisted drug development pipeline for challenging cancers with very few effective therapeutic options
29/05/24 → 28/05/25
Project: Research
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ABC-MDR-REVERSAL: Multidrug Resistance Reversal in Cancer Through a Novel Allosteric Mechanism
SANTOS, D. J. V. A. D. (PI), Rijo, P. D. M. (Researcher), Rosatella, A. D. A. (Researcher), Isca, V. M. S. (Researcher), Bangay, G. (Researcher) & Suzano, P. M. S. (Researcher)
31/01/24 → 31/07/25
Project: Research
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Exploring SAR insights into royleanones for P-gp modulation
Bangay, G., Isca, V. M. S., Brauning, F. Z., Dinic, J., Pesic, M., Palma, B. B., dos Santos, D. J. V. A., Díaz-Lanza, A. M., de Melo, E. B., Martins, J. P. A. & Rijo, P., Apr 2025, In: Biomedicine and Pharmacotherapy. 185, 117943.Research output: Contribution to journal › Article › peer-review
Open Access -
Extraction optimization and reactivity of 7α-acetoxy-6β-hydroxyroyleanone and ability of its derivatives to modulate PKC isoforms
Isca, V. M. S., Bangay, G., Princiotto, S., Saraíva, L., dos Santos, D. J. V. A., García-Sosa, A. T. & Rijo, P., 23 Jul 2024, In: Scientific Reports. 14, 1, p. 16990 16990.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Long-range communication between transmembrane- and nucleotide-binding domains does not depend on drug binding to mutant P-glycoprotein
Bonito, C. A., Ferreira, R. J., Ferreira, M. J. U., Gillet, J. P., Cordeiro, M. N. D. S. & dos Santos, D. J. V. A., 2023, In: Journal of Biomolecular Structure and Dynamics. 41, 23, p. 14428-14437 10 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Probing the Allosteric Modulation of P-Glycoprotein: A Medicinal Chemistry Approach Toward the Identification of Noncompetitive P-Gp Inhibitors
Bonito, C. A., Ferreira, R. J., Ferreira, M. J. U., Durães, F., Sousa, E., Gillet, J. P., Cordeiro, M. N. D. S. & dos Santos, D. J. V. A., 28 Mar 2023, In: ACS Omega. 8, 12, p. 11281-11287 7 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors
Espadinha, M., Lopes, E. A., Marques, V., Amaral, J. D., dos Santos, D. J. V. A., Mori, M., Daniele, S., Piccarducci, R., Zappelli, E., Martini, C., Rodrigues, C. M. P. & Santos, M. M. M., 5 Nov 2022, In: European Journal of Medicinal Chemistry. 241, 114637.Research output: Contribution to journal › Article › peer-review
Open Access23 Citations (Scopus)